Inaugurated in 2005 as part of a significant cultural enhancement initiative by Hawkesbury City Council, the Hawkesbury Regional Gallery has since become a prominent fixture in North-Western Sydney and the esteemed NSW Regional Galleries network. This transformative initiative involved the acquisition and meticulous restoration of the former Windsor Hospital, the development of the hospital site to house a contemporary library, art gallery, and café, as well as the creation of a state-of-the-art museum on Baker Street.

With a steadfast commitment to supporting regional and NSW artists, the Gallery predominantly curates exhibitions in-house, providing them with a platform to showcase their work to diverse audiences. Additionally, the Gallery hosts touring exhibitions from other esteemed regional and state galleries, as well as various touring organizations from across Australia, thereby ensuring that visitors are exposed to a wide range of artistic expressions.

Complementing the exhibition program, the Gallery also offers an array of engaging public and educational programs. These include engaging exhibition openings, enlightening talks by artists and curators, exclusive master classes led by accomplished artists, enriching studio visits, captivating art programs for children after school and during school holidays, and tailored education visits for school groups.

In its pursuit of enriching the cultural landscape of the region, the Hawkesbury Regional Gallery strives to provide a comprehensive and immersive experience for both artists and art enthusiasts, fostering a vibrant and inclusive artistic community.